Molecular basis of pancreas development and function

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Kluwer Academic , Norwell, Mass
Diabetes -- Molecular aspects., Pancreas -- Molecular aspects., Islets of Langerhans -- physiology., Endocrine Diseases -- physiopatho
Statementeditors, Joel F. Habener, Mehboob A. Hussain.
SeriesEndocrine updates -- 11
ContributionsHabener, Joel F., Hussain, Mehboob A.
Classifications
LC ClassificationsRC660 .M5613 2001
The Physical Object
Pagination412 p. :
ID Numbers
Open LibraryOL22462471M
ISBN 100792372719

Molecular Basis of Pancreas Development and Function (Endocrine Updates): Medicine & Health Science Books @ mat: Paperback. Development of β-cell Lines for Transplantation in Type 1 Diabetes Mellitus. Pages Efrat, Shimon, Ph.D. Molecular Basis of Pancreas Development and Function - Ebook written by Joel F.

Habener, Mehboob Hussain. Read this book using Google Play Books app on your PC, android, iOS devices. Download for offline reading, highlight, bookmark or take notes while you read Molecular Basis of Pancreas Development and Function.

Pancreas Pancreatic Islets biology diabetes diabetes mellitus growth growth factor homeostasis hormone insulin insulin resistance pathophysiology physiology protein Editors and affiliations Joel F. Molecular basis of pancreas development and function. Norwell, Mass.: Kluwer Academic, © (OCoLC) Material Type: Internet resource: Document Type: Book, Internet Resource: All Authors / Contributors: Joel F Habener; Mehboob A Hussain.

Download Citation | Molecular Basis of Pancreas Development and Function | Diabetes mellitus is rapidly increasing in prevalence throughout both developed and developing countries. The pancreas is an essential endoderm-derived organ that ensures nutrient metabolism via its endocrine and exocrine functions.

Here we review the essential processes governing the embryonic and early postnatal development of the pancreas discussing both the mechanisms and molecules controlling progenitor specification, expansion and differentiation. Buy Molecular Basis of Pancreas Development and Function (Endocrine Updates) by Habener, Joel F., Hussain, Mehboob (ISBN: ) from Amazon's Book Store.

Everyday low prices and free delivery on eligible : Hardcover. Molecular Nutrition and Diabetes: A Volume in the Molecular Nutrition Series focuses on diabetes as a nutritional problem and its important metabolic consequences.

Fuel metabolism and dietary supply all influence the outcome of diabetes, but understanding the pathogenesis of the diabetic process is a prelude to better nutritional control. The molecular and morphogenetic basis of pancreas The pancreas is an essential endoderm-derived organ that ensures nutrient metabolism via its endocrine and exocrine functions.

Here we review the essential processes governing the embryonic and early postnatal development of the pancreas discussing both the mechanisms and molecules. The genetic dissection of pancreas development and β-cell function in mouse has provided valuable information on the basic mechanisms of organogenesis, mature β-cell function and maintenance of.

The TF network has been well characterized in the pancreas, especially regarding β-cell development, with many TFs exhibiting dual roles during development and adult function. In early development, specific TFs govern the establishment and maintenance of the MPCs, while in mature tissue, TFs affect cell specific by: 1.

The purpose of Molecular Basis of Pancreas Development and Function is to bring together the many different aspects of and the recent discoveries in the understanding of pancreatic endocrine development and its close links to endocrine cell physiology and dysfunction in diabetes.

Molecular Basis of Pancreas Development and Function. Soluble Factors Important for Pancreas Development. In: Habener J.F., Hussain M.A.

(eds) Molecular Basis of Pancreas Development and Function. Endocrine Updates, vol Springer, Boston, MA. First Online 12 April ;Cited by: 1. Entdecken Sie "Molecular Basis of Pancreas Development and Function" von Joel F. Habener und finden Sie Ihren Buchhändler.

Diabetes mellitus is rapidly increasing in prevalence throughout both developed and developing countries. The social and economic burden of this disease is estimated to cost 14 billion dollars worldwide.

In the USA alone, 15 million individuals are diabetic, nearly half. He has published over manuscripts and recently co-edited two books on inherited diseases of the pancreas. He is a Counselor for the American Gastroenterology Association (AGA), the American Pancreas Association and the International Association of Pancreatology, and is Chairman of the Pancreatic Disorders Section of the AGA.

Molecular Pathology: The Molecular Basis of Human Disease provides a current and comprehensive view of the molecular basis and mechanisms of human disease. Combining accepted principles with broader theoretical concepts and with contributions from a group of experts, the book looks into disease processes in the context of traditional pathology and their implications for translational molecular.

Summary This chapter contains sections titled: Introduction Alterations in oncogenic pathways Tumor‐suppressor genes/pathways Pancreas development and how this has contributed to our advanced under.

Description Molecular basis of pancreas development and function FB2

Figure Pancreas The pancreatic exocrine function involves the acinar cells secreting digestive enzymes that are transported into the small intestine by the pancreatic duct. Its endocrine function involves the secretion of insulin (produced by beta cells) and glucagon (produced by alpha cells) within the pancreatic islets.

The pancreas is an endoderm-derived glandular organ that participates in the regulation of systemic glucose metabolism and food digestion through the function of its endocrine and exocrine compartments, respectively. While intensive research has explored the signaling pathways and transcriptional programs that govern pancreas development, much remains to be discovered.

This chapter highlights the factors that can contribute to the development of chronic pancreatitis and provides an overview of the molecular basis of diseases of the exocrine pancreas. Do you want. Removal of the underlying disease-causing agent results in complete regeneration of the pancreas and preserved exocrine and endocrine function in the majority of cases.

Recurrent attacks of the disease can result from chronic alcohol abuse, repeated gallstone passage, genetic predispositions, sphincter dysfunction, metabolic disorders, or pancreatic duct : Matthias Sendler, Julia Mayerle, Markus M.

Lerch. The pancreas is a two-headed organ, not only in origin but also in function.

Details Molecular basis of pancreas development and function PDF

In origin, the pancreas develops from two separate primordia. In function, the organ has both endocrine function in relation to regulating blood glucose (and also other hormone secretions) and gastrointestinal function as an exocrine (digestive) organ, see exocrine pancreas.

The first tumor type of the pancreas to be sequenced was invasive ductal adenocarcinoma. In a real tour de force, Jones et al.

used PCR amplification and Sanger sequencing to analyze the exomes of twenty-four invasive ductal adenocarcinomas of the pancreas, and the hits from the exome sequencing were validated in another 90 pancreatic cancers 4.

eBook is an electronic version of a traditional print book THIS can be read by using a personal computer or by using an eBook reader. (An eBook reader can be a software application for use on a computer such as Microsoft's free Reader application, or a book-sized computer THIS is used solely as a reading device such as Nuvomedia's Rocket eBook.).

Although the primary function of the circulatory system in the pancreas is the exchange of nutrients, wastes and gases, additional roles for blood vessels during pancreas development and tissue homeostasis have been discovered in recent years, paralleling discoveries in.

This section of notes gives an overview of how the pancreas develops as an exocrine organ associated with the gastrointestinal tract. There is a second description, similar in overview, in relation to the pancreas as an endocrine organ, see Endocrine - Pancreas Development.

At the foregut/midgut junction the septum transversum generates 2 pancreatic buds (dorsal and ventral endoderm) which. Oncogenes and tumor suppressors—and the mutations that affect them—are different beasts from the point of view of the cancer gene hunter.

But from a cancer cell's point of view they are two sides of the same target. The same kinds of effects on cell behavior can result from mutations in either class of genes, because most of the control mechanisms in the cell involve both inhibitory (tumor.

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Epstein's Inborn Errors of Development The Molecular Basis of Clinical Disorders of Morphogenesis. Third Edition. Edited by Robert P. Erickson, MD and Anthony J. Wynshaw-Boris, MD, PhD Oxford Monographs on Medical Genetics.

Emphasizes the developmental roles of genes in the causation of hereditary conditions affecting appearance and function.

Molecular basis of cancer part 1 1. MOLECULAR BASIS OF CANCER PART 1 DR. GANGADHAR CHATTERJEE 2. Neoplasia means “new growth” Greek oncos = tumor British oncologist Willis gave closest definition-―A neoplasm is an abnormal mass of tissue, the growth of which exceeds and is uncoordinated with that of the normal tissues and persists in the same excessive manner after.

Hlxb9 in pancreatic development reveals a molecular dis-tinction in the dorsal and ventral differentiation programs and sequential Hlxb9 functions at both early and late stages of pan-creatic differentiation.

The selective ablation of the dorsal pancreas is striking in view of .To shed further light on the primary alterations of insulin secretion in type 2 diabetes and the possible mechanisms involved, we studied several functional and molecular properties of islets isolated from the pancreata of 13 type 2 diabetic and 13 matched nondiabetic cadaveric organ donors.

Glucose-stimulated insulin secretion from type 2 diabetic islets was significantly lower than from.The pancreas is a long, slender organ, most of which is located posterior to the bottom half of the stomach ().Although it is primarily an exocrine gland, secreting a variety of digestive enzymes, the pancreas has an endocrine function.

Its pancreatic islets—clusters of cells formerly known as the islets of Langerhans—secrete the hormones glucagon, insulin, somatostatin, and pancreatic.